During June and July 1991, more than 400 laboratory-confirmed Salmonella Poona infections occurred in 23 states and Canada (Ontario, Newfoundland, Quebec, Saskatchewan). Illness was associated with eating cut up cantaloupe in salad bars or fruit salads. At least 72 of the cases were in Canada. Salmonella was never isolated from cantaloupe as the produce had been consumed, or discarded, before the epidemiologic investigations began. Although industry sources identified the lower Rio Grande Valley, in Texas, as the probable source of the implicated cantaloupes, some cantaloupes may have come from Mexico.