Multiple people, residing in several states, had become ill with Shigella after their stay at the Doubletree Hotel in Westminster, Colorado. Several groups were affected including hotel staff, a veterans' group, a wedding group, and other hotel guests. The same strain of Shigella was detected among the culture confirmed cases. During the investigation, the hotel kitchen closed while staff were tested for shigella. At least three food handlers were found to have Shigella in their stool. The kitchen was sanitized and high risk foods were discarded. The epidemiologic investigation determined that the illnesses were associated with eating from the breakfast buffet. Most likely honeydew melon was the source of illness. During environmental assessments, staff inconsistently sanitized melons prior to serving. The honeydew melons were traced to two farms in California, but the investigation was inconclusive as to the possible source of contamination at those farms.