In July 2014 public health investigators in California learned of an increase of case patients diagnosed with Salmonella serotype Montevideo. The California Department of Public Health (CDPH) Microbial Disease Laboratory (MDL) conducted pulsed field gel electrophoresis (PFGE) on isolates cultured from patient specimens. Seven patients were infected with an indistinguishable genetic strain identified as JIXX01.0645, an uncommon genetic strain. Patients resided in Ventura and Los Angeles counties. Information gathered in interviews conducted by local health investigators revealed that just prior to onset of symptoms; all seven patients had eaten at Brent’s Deli, a restaurant located in Westlake Village, California. Health officials initiated active surveillance of patients diagnosed with Salmonella Montevideo strain JIXX01.0645. In total 19 patients infected with strain JIXX01.0645 were identified. Two additional patients were infected with strain JIXX01.1565, considered to be a clonal derivative of the main outbreak strain. Two of the 21 patients were employees of Brent’s Deli. Eight patients were hospitalized. Dates of illness onset ranged from April 30, 2014 to August 15, 2014.