In November 2015 the North Carolina Division of Public Health, the North Carolina State Laboratory for Public Health and the Pitt County Department of Health investigated an outbreak of Clostridium perfringens among attendees at a catered Thanksgiving lunch. Fifty eight f the 80 attendees completed a survey about illness and foods consumed. Forty four respondents reported illness including 41 with diarrhea and 40 with abdominal pain. There were no hospitalizations or deaths. C. perfringens enterotoxin gene was recovered from 5 stool specimens and 4 turkey samples. Risk for illness among persons who ate turkey or stuffing which was plated and served together, was significantly higher than risk for illness among those who did not eat turkey or stuffing.