In 2018 the CDC and multiple states investigated outbreaks of Salmonella infections linked to contact with live poultry in backyard flocks. Several different serotypes of Salmonella were isolated in patients in the outbreak: Salmonella Senftenberg, Salmonella Montevideo Salmonella Infantis, Salmonella Enteritidis, Salmonella Indiana and Salmonella Litchfield. Illnesses started on dates ranging from February 2, 2018 to August 10, 2018. A total of 334 people were infected with outbreak strains of Salmonella reported by 47 states. Fifty six people were hospitalized, and no deahts were reported.

Epidemiologic, traceback, and laboratory findings linked these outbreaks to contact with live poultry such as chicks and ducklings which were from multiple hatcheries.

Whole genome sequencing analysis was performed on 141 isolates from ill people in this outbreak. Twenty-eight isolates contained genes that predict resistance to at least one of the following antibiotics: ampicillin, streptomycin, sulfamethoxazole, tetracycline, gentamicin, ceftriaxone, amoxicillin-clavulanic acid, cefoxitin, ciprofloxacin, and fosfomycin. No resistance was identified in 113 isolates.

The outbreaks were declared over on September 13, 2018.